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Jets X-Factor. Home Analytics. The Baylor product has eight catches in eight games with zero touchdowns. Eliminate basic mistakes Mims ranks th among wide receivers in offensive snaps played this season Join the official Discord community to connect with likeminded fans. Grading every Zach Wilson throw vs. Buffalo Bills. The overlooked NY Jets need that nobody is talking about.
Ranking every key NY Jets player in from worst to best. It has been observed that there is variation in the quantity and quality of information mentioned in different drug information sources and a single credible benchmark is lacking. Such variation not only deprives the medical fraternity from accessing reliable drug information but can also promote off-label and irrational drug use leading to increased incidence of adverse reactions and possible treatment failure.
We identified 50 commonly used drugs belonging to different groups e. These drugs were chosen on the basis of prescription pattern in the hospital. Two senior residents D. Clinical Pharmacology students and one PhD student collected and analyzed the PIs of the selected drugs.
The following parameters were assessed. The number of drugs out of the selected 50, whose indication information was missing in different sources. In the next step, we compared only those drugs whose indications were mentioned in all the four sources. We also looked upon gross qualitative differences existing across various sources of drug information used in this study.
To find the difference between different sources, data were statistically analyzed by applying Friedman Test using Graph Pad Instat trial version software. PIs of all the 50 selected drugs were collected, and they had information about indications which was included in the analysis for comparison. Only MIMS contained information about all the 50 drugs. The number of indications per drug was variable in all these four sources. The details of this information are given in Table 1.
NFI was excluded from this analysis as this source had information of only about 24 of these 40 drugs. In respect of these 40 drugs, the PI had listed maximum number of indications 2. To include NFI as well, a subset analysis was done in respect of those 24 drugs information about which were available in all the four sources including NFI. We found that NFI had listed maximum number of indications 3.
After the quantitative comparison, we identified any gross qualitative mismatch in information across these four sources. Following gross discrepancies are observed:.
Of the 40 drugs mentioned in CDSCO, only broad single indication is mentioned in respect of some drugs e. It is apparent that such abridged information only reflects the broad use of the drug without providing more specific and relevant information to the prescribing physicians. Labetalol is one of the preferred drugs for treatment of pregnancy induced hypertension, and its oral administration is considered as safe and effective as methyldopa. Surprisingly, NFI lists out the maximum indications for fluoxetine which includes premenstrual disorder, anorexia nervosa, and Parkinson's disease as well over and above the indications given in other three sources.
For tablet topiramate, the CDSCO site mentions it only as an antiepileptic, whereas other sources go on to describe the type of epileptic disorders for which it is indicated. In addition, PI mentions prophylaxis of migraine as one of its indication. Besides above variations, some minor typographical errors were also noticed in information provided in CDSCO, e. In India, Drugs Controller General of India is the drug regulatory authority who is responsible for granting approval and marketing permission of drugs in our country.
The drugs are approved by drug regulator of any country for specific indications in specified dosage, which is known as the labeling information of that particular drug. However, the actual use of the drug in clinical practice may vary and may not be according to its labeling information at times. For example, metformin is used for the treatment of polycystic ovarian disease which is not its approved indication. Such a use of an approved drug is known as off-label use.
Off-label use of a drug is not illegal, however, it may be irrational or unscientific. In order to promote the rational and scientific use of drugs, it is important that relevant information about any drug, namely its indications, contraindications, and dosage are readily available to the prescribing physicians.
We undertook this study to assess the quantity and quality of drug information available in various sources and compared it with the labeling information of the drug as provided in the CDSCO website, which is the regulatory benchmark.
The information about indications was taken as the sole benchmark of overall drug information, and various sources were compared on the basis of this parameter. It was observed that no information about indications of 10 out of the selected 50 drugs was available on the CDSCO website. You can find free music in a few seconds. It is enough only to enter the name or creative pseudonym of the musician or the collective in the search string.
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